Structure and Functions of the 20S and 26S Proteasomes

Structure and Functions of the 20S and 26S Proteasomes. proteasome regulation and demonstrate the biological significance of proteasome phosphorylation in regulating cell proliferation and tumorigenesis. Introduction The 26S proteasome is an essential protein complex responsible for degrading the majority of cellular proteins in eukaryotes1. An impaired proteasome system often underlies neurodegenerative diseases and the aging …