Furthermore, although and proteases can release biologically active C5a from C5 (which leads to immune evasion and inflammation), the generated C5b component is degraded by the same proteases (Arg-specific gingipains HRgpA and RgpB and karilysin), thereby preventing the generation of MAC

Furthermore, although and proteases can release biologically active C5a from C5 (which leads to immune evasion and inflammation), the generated C5b component is degraded by the same proteases (Arg-specific gingipains HRgpA and RgpB and karilysin), thereby preventing the generation of MAC. In summary, clinical and histological studies in human patients are consistent with the involvement …